Faculty Part-Time Faculty Alumni




Office No:

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A-801

0216 578 00 85

nihan.olcum@yeditepe.edu.tr

www.researchgate.net/profile/Nihan_Celebi-Oelcuem

www.twitter.com/NCelebiOlcum


Education:


B.Sc., Bogaziçi University, Turkey

M.Sc., Université Henri Poincaré , France

Ph.D., Bogazici University, Turkey


Academic Background:


2012-               Assistant Professor
Yeditepe University, Department of Chemical Engineering, Istanbul, Turkey
           
2009-2012       Postdoctoral Researcher
University of California, Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA
           
2008-2009       Zeynep-Ayse Birkan Graduate Fellow
Bogaziçi University, Department of Chemistry, Istanbul, Turkey, and University of California, Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA
           
2006-2007       TUBITAK International Research Fellow
University of California, Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA
           
2005-2008       Research Assistant
Bogaziçi University, Department of Chemistry, Istanbul, Turkey


Publications:


19. Zhang, S.; Melzer, M. M.; Sen, S. N.; Çelebi-Ölçüm, N.; Warren, T. H. “A Motif for Reversible Nitric Oxide Interactions in Metallozymes” Nature Chem. 2016, Accepted

18. Richmond, E; Ling, K. B.; Duguet, N.; Manton L.; Çelebi-Ölçüm, N.; Lam, Y.-H.; Alsancak, S.; Slawin, A. M. Z.; Houk, K. N.; Smith, A. D. “An Asymmetric Pericyclic Cascade Approach to 3-Alkyl-3-Aryloxindoles: Generality, Application, and Mechanistic Investigations” Org. Biomol. Chem. 2015, 13, 1807-1817. (10.1039/c4ob02526a)

17.Zhang, S.; Çelebi-Ölçüm, N.; Melzer. M. M.; Houk, K. N.; Warren, T. H.“Copper(I) Nitrosyls from Reaction of Copper(II) Thiolates with S-Nitrosothiols: Mechanism of NO Release from RSNOs at Cu” J. Am. Chem. Soc. 2013, 135, 16746-16749. (10.1021/ja406476y)

16. Bjelic, S.; Nivon, L. G.; Çelebi-Ölçüm, N.; Kiss, G.; Rosewall, C. F.; Lovick, H. M.; Ingalls, E. L.; Gallaher, J. L.; Seetharaman, J.; Lew, S.; Montelione, G. T.; Hunt, J. F.; Michael, F. E.; Houk, K. N.; Baker, D. “Computational Design of Enone-Binding Proteins with Catalytic Activity for the Morita-Baylis-Hillman Reaction” ACS Chem. Biol. 2013, 8, 749-757. (10.1021/cb3006227)

15. Kiss, G.; Çelebi-Ölçüm, N.; Moretti, R.; Baker, D.; Houk, K. N. “Computational Enzyme Design”, Angew. Chem. Int. Ed. 2013, 52, 5700-5725. (10.1002/anie.201204077).
           
14. Kheirabadi, M.; Çelebi-Ölçüm, N.; Parker, M. F. L.; Zhao, Q.; Kiss, G.; Houk, K. N.; Schafmeister, C. E. “Spiroligozymes for Transesterfications: Design and Relationship of Structure to Activity”, J. Am. Chem. Soc. 2012, 134, 18345-18353. (10.1021/ja3069648)
           
13. Bellomo, A.; Çelebi-Ölçüm, N.; Bu, X.; Rivera, N.; Ruck, R.; Welch, C. J.; Houk, K. N.; Dreher, S. D. “Rapid Catalyst Identification for the Synthesis of the Pyrimidinone Core of HIV Integrase Inhibitors”, Angew. Chem. Int. Ed. 2012, 51, 6912-6915. (10.1002/anie.201201720)
           
12. Çelebi-Ölçüm, N.; Lam, Y. –H.; Richmond, E.; Ling, K. B.; Smith, A. D.; Houk, K. N. “Pericyclic Cascade with Chirality Transfer: Reaction Pathway and Origin of Enantioselectivity of the Hetero-Claisen Approach to Oxindoles”, Angew. Chem. Int. Ed. 2011, 50, 11478-11482. (10.1002/anie.201105412)
           
11. Agopcan, S.; Çelebi-Ölçüm, N.; Ucisik, M. N.; Sanyal, A.; Aviyente, V. “ Origins of the Diastereoselectivity in the Hydrogen Bonding Directed Diels-Alder Reactions of Chiral Dienes with Achiral Dienophiles: A Computational Study”, Org. Biomol. Chem. 2011, 9, 8079-8088. (10.1039/C1OB06285A)
           
10. Cheong, P. H. -Y.; Legault, C. Y.; Um, J.; Çelebi-Ölçüm, N.; Houk, K. N. “Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities”, Chem. Rev. 2011, 111, 5042-5137. (10.1021/cr100212h)
           
9. Kiss, G.; Johnson, S. A.; Nosrati, G.; Çelebi-Ölçüm, N.; Kim, S.; Paton, R.; Houk, K. N. “Computational design of new protein catalysts” In Modeling of Molecular Properties; Comba P., Ed.; Wiley-VCH, 2011; pp. 243-266. (10.1002/9783527636402.ch16)
           
8. Çelebi-Ölçüm, N.; Boal, B. W.; Huters, A. D.; Garg, N. K.; Houk, K. N. “Why do some Fischer indolizations fail?”, J. Am. Chem. Soc. 2011, 133, 5752-5755. (10.1021/ja201035b)
           
7. Çelebi-Ölçüm, N.; Aviyente, V.; Houk, K. N. “Mechanism and selectivity of cinchona alkaloid catalyzed [1,3]-shifts of allylic trichloroacetimidates”, J. Org. Chem. 2009, 74, 6944-6952. (10.1021/jo901109s)
           
6. Çelebi-Ölçüm, N.; Sanyal, A.; Aviyente V. “Understanding the stereoselection induced by chiral anthracene templates in Diels-Alder reactions: A DFT study”, J. Org. Chem. 2009, 74, 2328-2336. (10.1021/jo802365v)
           
5. Çelebi-Ölçüm, N.; Ess, D. H.; Aviyente, V.; Houk, K. N. “Effect of Lewis acid catalysts on Diels-Alder and hetero-Diels-Alder cycloadditions sharing a common transition state”, J. Org. Chem. 2008, 73, 7472-7480. (10.1021/jo801076t)
           
4. Ess, D. H.; Wheeler, S. E.; Iafe, R. G.; Xu, L.; Çelebi-Ölçüm, N.; Houk, K. N. “Bifurcations on the potential energy surfaces of organic reactions”, Angew. Chem. Int. Ed. 2008, 47, 7592-7601. (10.1002/anie.200800918)
           
3. Yeniad, B.; Albayrak, A. Z.; Çelebi-Ölçüm, N.; Avci, D. “Synthesis and photopolymerizations of new phosphonated monomers for dental applications”, J. Polym. Sci. Part A: Polym. Chem. 2008, 46, 2290-2299. (10.1002/pola.22564)
           
2. Çelebi-Ölçüm, N.; Ess, D. H.; Aviyente, V.; Houk, K. N. “Lewis acid catalysis alters the shapes and products of bis-pericyclic Diels-Alder transition states”, J. Am. Chem. Soc. 2007, 129, 4529-4530. (10.1021/ja070686w)
           
1. Çelebi, N.; Dehez, F.; Millot, C.; Angyan, J. G.; Chipot, C. “Distributed polarizabilities derived from induction energies: a finite perturbation approach”, J. Chem. Phys. 2000, 112, 2709-2717. (10.1063/1.480845)